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Emily Chen

Director of Proteomics Shared Resource
Provide mass spectrometry-based analysis to analyze post-translational modifications (PTMs) of single protein, protein complexes, large-scale proteome and PTM proteome.

Multidiscipline Bridging Protein biochemistry biomarker development oncology cell biology translational research

Services and Resources Offered

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Recent Posts

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Publications

"hMENA isoforms impact NSCLC patient outcome through fibronectin/beta1 integrin axis.", Oncogene, , (2018)
"miR-195 Regulates Metabolism in Failing Myocardium via Alterations in SIRT3 Expression and Mitochondrial Protein Acetylation.", Circulation, , (2018)
"Serum exosomal protein profiling for the non-invasive detection of cardiac allograft rejection.", J Heart Lung Transplant, , (2017)
"Regulation of Mitochondrial Complex I Biogenesis in Drosophila Flight Muscles.", Cell Rep, 20(1), 264-278 (2017)
"Rap1b is an effector of Axin2 regulating crosstalk of signaling pathways during skeletal development.", J Bone Miner Res, , (2017)
"Proteomics Analysis of Circulating Serum Exosomes.", Methods Mol Biol, 1619, 213-225 (2017)
"Acquired resistance to innate immune clearance promotes Klebsiella pneumoniae ST258 pulmonary infection.", JCI Insight, 1(17), e89704 (2016)
"Identifying Urinary and Serum Exosome Biomarkers for Radiation Exposure Using a Data Dependent Acquisition and SWATH-MS Combined Workflow.", Int J Radiat Oncol Biol Phys, , (2016)
"New insight into the role of MMP14 in metabolic balance.", PeerJ, 4, e2142 (2016)
"Auto-thiophosphorylation activity of Src tyrosine kinase.", BMC Biochem, 17(1), 13 (2016)
"Mitogen-activated protein kinase signaling causes malignant melanoma cells to differentially alter extracellular matrix biosynthesis to promote cell survival.", BMC Cancer, 16(1), 186 (2016)
"Lambda Interferon Restructures the Nasal Microbiome and Increases Susceptibility to Staphylococcus aureus Superinfection.", MBio, 7(1), (2016)
"Asparagine deprivation mediated by Salmonella asparaginase causes suppression of activation-induced T cell metabolic reprogramming.", J Leukoc Biol, , (2015)
"Cellular STAT3 functions via PCBP2 to restrain Epstein-Barr Virus lytic activation in B lymphocytes.", J Virol, 89(9), 5002-5011 (2015)
"The Tumor Suppressor NKX3.1 Is Targeted for Degradation by DYRK1B Kinase.", Mol Cancer Res, 13(5), 913-922 (2015)
"FBXW7 modulates cellular stress response and metastatic potential through HSF1 post-translational modification.", Nat Cell Biol, 17(3), 322-332 (2015)
"Intestinal microbiota-derived metabolomic blood plasma markers for prior radiation injury.", Int J Radiat Oncol Biol Phys, 91(2), 360-367 (2015)
"Identifying Predictors of Taxane-Induced Peripheral Neuropathy Using Mass Spectrometry-Based Proteomics Technology.", PLoS One, 10(12), e0145816 (2015)
"Identification of thioridazine, an antipsychotic drug, as an antiglioblastoma and anticancer stem cell agent using public gene expression data.", Cell Death Dis, 6, e1753 (2015)
"SCCA1/SERPINB3 promotes oncogenesis and epithelial-mesenchymal transition via the unfolded protein response and IL6 signaling.", Cancer Res, 74(21), 6318-6329 (2014)
"N-cadherin promotes recruitment and migration of neural progenitor cells from the SVZ neural stem cell niche into demyelinated lesions.", J Neurosci, 34(29), 9590-9606 (2014)
"Keratin 17 in premalignant and malignant squamous lesions of the cervix: proteomic discovery and immunohistochemical validation as a diagnostic and prognostic biomarker.", Mod Pathol, 27(4), 621-630 (2014)
"Neurotrophin-3 modulates breast cancer cells and the microenvironment to promote the growth of breast cancer brain metastasis.", Oncogene, 32(35), 4064-4077 (2013)
"Biochemical characterization of Hpa2 and Hpa3, two small closely related acetyltransferases from Saccharomyces cerevisiae.", J Biol Chem, 288(30), 21506-21513 (2013)
"The perivascular niche regulates breast tumour dormancy.", Nat Cell Biol, 15(7), 807-817 (2013)
"The hemopexin domain of MMP3 is responsible for mammary epithelial invasion and morphogenesis through extracellular interaction with HSP90beta.", Genes Dev, 27(7), 805-817 (2013)
"Members of the high mobility group B protein family are dynamically expressed in embryonic neural stem cells.", Proteome Sci, 11(1), 18 (2013)
"The Aurora kinases inhibitor VE-465 is a novel treatment for glioblastoma multiforme.", Oncology, 84(6), 326-335 (2013)
"Regulation of pluripotency and cellular reprogramming by the ubiquitin-proteasome system.", Cell Stem Cell, 11(6), 783-798 (2012)
"Mitochondrial dysfunction and cancer metastasis.", J Bioenerg Biomembr, 44(6), 619-622 (2012)
"Early-stage epigenetic modification during somatic cell reprogramming by Parp1 and Tet2.", Nature, 488(7413), 652-655 (2012)
"Hnrpab regulates neural development and neuron cell survival after glutamate stimulation.", RNA, 18(4), 704-719 (2012)
"Tuftsin promotes an anti-inflammatory switch and attenuates symptoms in experimental autoimmune encephalomyelitis.", PLoS One, 7(4), e34933 (2012)
"Detecting the immune system response of a 500 year-old Inca mummy.", PLoS One, 7(7), e41244 (2012)
"Macroautophagy deficiency mediates age-dependent neurodegeneration through a phospho-tau pathway.", Mol Neurodegener, 7, 48 (2012)
"Cancer stem cells, tumor dormancy, and metastasis.", Front Endocrinol (Lausanne), 3, 125 (2012)
"The plasminogen receptor, Plg-R(KT), and macrophage function.", J Biomed Biotechnol, 2012, 250464 (2012)
"Ling Zhi-8 mediates p53-dependent growth arrest of lung cancer cells proliferation via the ribosomal protein S7-MDM2-p53 pathway.", Carcinogenesis, 32(12), 1890-1896 (2011)
"Raf-induced MMP9 disrupts tissue architecture of human breast cells in three-dimensional culture and is necessary for tumor growth in vivo.", Genes Dev, 24(24), 2800-2811 (2010)
"Proteomics-based discovery of a novel, structurally unique, and developmentally regulated plasminogen receptor, Plg-RKT, a major regulator of cell surface plasminogen activation.", Blood, 115(7), 1319-1330 (2010)
"Spatiotemporal expression of the serine protease inhibitor, SERPINE2, in the mouse placenta and uterus during the estrous cycle, pregnancy, and lactation.", Reprod Biol Endocrinol, 8, 127 (2010)
"Identification of a stem-like cell population by exposing metastatic breast cancer cell lines to repetitive cycles of hypoxia and reoxygenation.", Breast Cancer Res, 12(6), R94 (2010)
"GO Explorer: A gene-ontology tool to aid in the interpretation of shotgun proteomics data.", Proteome Sci, 7, 6 (2009)
"Comparisons of mass spectrometry compatible surfactants for global analysis of the mammalian brain proteome.", Anal Chem, 80(22), 8694-8701 (2008)
"PatternLab for proteomics: a tool for differential shotgun proteomics.", BMC Bioinformatics, 9, 316 (2008)
"Cancer proteomics by quantitative shotgun proteomics.", Mol Oncol, 1(2), 144-159 (2007)
"Optimization of mass spectrometry-compatible surfactants for shotgun proteomics.", J Proteome Res, 6(7), 2529-2538 (2007)
"Adaptation of energy metabolism in breast cancer brain metastases.", Cancer Res, 67(4), 1472-1486 (2007)
"Involvement of Bcl-X(L) deamidation in E1A-mediated cisplatin sensitization of ovarian cancer cells.", Oncogene, 25(18), 2656-2665 (2006)
"Large scale protein profiling by combination of protein fractionation and multidimensional protein identification technology (MudPIT).", Mol Cell Proteomics, 5(1), 53-56 (2006)
"Maspin and tumor metastasis.", IUBMB Life, 58(1), 25-29 (2006)
"Genetic reprogramming of tumor cells by zinc finger transcription factors.", Proc Natl Acad Sci U S A, 102(33), 11716-11721 (2005)
"Maspin alters the carcinoma proteome.", FASEB J, 19(9), 1123-1124 (2005)
"Psychiatric aspects of women with breast cancer.", Psychiatr Clin North Am, 26(3), 713-24, viii (2003)
"A residue in the S2 subsite controls substrate selectivity of matrix metalloproteinase-2 and matrix metalloproteinase-9.", J Biol Chem, 278(19), 17158-17163 (2003)
"A unique substrate binding mode discriminates membrane type-1 matrix metalloproteinase from other matrix metalloproteinases.", J Biol Chem, 277(26), 23788-23793 (2002)
"Sensitivity of p53-deficient cells to oxaliplatin and thio-TEPA (N, N', N" triethylenethiophosphoramide).", Breast Cancer Res Treat, 72(3), 255-263 (2002)
"A unique substrate recognition profile for matrix metalloproteinase-2.", J Biol Chem, 277(6), 4485-4491 (2002)
"Large-scale purification of prothoracicotropic hormone of the silkworm (Bombyx mori).", Sci Sin, 23(8), 1053-1060 (1980)

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