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MicroRNAs (miRNA) are non-coding ribonucleic acids (RNA) that average 22 nucleotides long, and are found to be circulating at certain levels in the blood. Due to their stability, circulating miRNA have become attractive biomarkers for disease.
microRNAs regulate gene expression by binding to complimentary targets of messenger-RNA (mRNA). micro RNA regulates gene expression by degrading messenger RNA or repressing translation.
Each micro RNA has multiple messenger RNA targets.
micro RNAs rare stable in blood, plasma, serum and other body fluids or tissues.